SNAP-8

They are unrelated peptides used in cosmetic-science research. SNAP-8 (acetyl octapeptide-3) is an eight-amino-acid peptide modeled on the N-terminal end of the protein SNAP-25 and studied for its interaction with the SNARE complex that controls neurotransmitter release. GHK-Cu is a copper complex of the tripeptide Gly-His-Lys, studied in copper transport and extracellular-matrix research. SNAP-8 is not a component of the GHK-Cu blends we sell.

SNAP-8 is the trade name of acetyl octapeptide-3, Ac-Glu-Glu-Met-Gln-Arg-Arg-Ala-Asp-NH2, a synthetic eight-amino-acid peptide developed by the Spanish company Lipotec as a cosmetic ingredient. Its sequence mimics the N-terminal end of SNAP-25, a protein in the SNARE complex that drives the fusion of neurotransmitter vesicles with the cell membrane. The figure on the label, such as 10 mg, is the amount of peptide in the vial.

Yes. SNAP-8 is an octapeptide: eight amino acids, with an acetyl cap on the N-terminus and an amide on the C-terminus. Its cosmetic ingredient (INCI) name, acetyl octapeptide-3, says the same thing. Like other synthetic peptides, it is made by solid-phase peptide synthesis and its identity is confirmed by mass spectrometry.

No. SNAP-8 is not a drug and has not been approved by the FDA. It is sold as a cosmetic ingredient, and the FDA does not approve cosmetic ingredients before they go on the market. The material sold here is a research reagent for laboratory use.

Research on SNAP-8 has been mainly in vitro, examining whether the peptide competes with SNAP-25 for a place in the SNARE complex and so interferes with vesicle fusion, along with cosmetic-science studies, many of them by the ingredient's manufacturer. It has not been through drug clinical trials. Findings in cells do not establish effects in people.

They are closely related. Argireline is acetyl hexapeptide-3 (also listed as -8), Ac-Glu-Glu-Met-Gln-Arg-Arg-NH2, six amino acids from the N-terminus of SNAP-25. SNAP-8 is its extension by two more residues, Ala-Asp, giving acetyl octapeptide-3. SNAP-8 is not Argireline, but it was developed from it by the same company.

No. Botulinum toxin is a large bacterial protein of about 150 kDa that enters nerve cells and enzymatically cleaves SNAP-25. SNAP-8 is a small synthetic octapeptide of about 1 kDa that copies a short stretch of SNAP-25's sequence. Both relate to the same SNARE protein, but they are completely different molecules with different mechanisms.

They are different cosmetic peptides with different targets. SNAP-8 is an octapeptide modeled on SNAP-25 in the SNARE complex. Syn-Ake is the trade name of dipeptide diaminobutyroyl benzylamide diacetate, a small synthetic molecule modeled on waglerin-1, a temple-viper venom peptide, and studied as an antagonist of the muscle nicotinic acetylcholine receptor.

They belong to different groups of cosmetic peptides. SNAP-8 (acetyl octapeptide-3) is modeled on the SNARE protein SNAP-25. Matrixyl is the trade name of palmitoyl pentapeptide-4, Pal-Lys-Thr-Thr-Lys-Ser, a fragment of type I procollagen attached to a palmitic acid chain; it is classed as a signal peptide and studied in extracellular-matrix research.

Yes, for storage. Keep sealed lyophilized SNAP-8 refrigerated at 2–8 °C, or frozen at −20 °C for long-term storage. Its methionine residue is prone to oxidation, so keep vials sealed and away from light, keep reconstituted material refrigerated, and avoid repeated freeze-thaw cycles.

SNAP-8: molecular formula C41H70N16O16S; molecular weight 1075.2 g/mol; CAS number 868844-74-0. Sequence: Ac-Glu-Glu-Met-Gln-Arg-Arg-Ala-Asp-NH2 (Ac-EEMQRRAD-NH2). Match these identifiers against the Certificate of Analysis for the lot.

Yes. Each lot has its own Certificate of Analysis, linked on this page for the current lot of each size: 10mg (98.74% HPLC purity). Past certificates are archived in the COA library; contact us with the lot number on the vial label if a certificate is missing.

98.74% (HPLC, current lot). Purity is measured by high-performance liquid chromatography (HPLC) and reported on the lot's Certificate of Analysis.

SNAP-8 is supplied as lyophilized powder in a sealed vial: 10mg. In stock and dispatched in 1–2 business days. Quantity pricing applies automatically at 5+ and 10+ vials of the same size.

Store sealed at −20 °C, dry and protected from light.