KISSPEPTIN-10 (fragment)

Kisspeptin-10 is a synthetic decapeptide, YNWNSFGLRF-NH2: the ten C-terminal amino acids of kisspeptin, the protein encoded by the KISS1 gene. It is the shortest fragment with full activity at the kisspeptin receptor (KISS1R, also called GPR54) and is studied in reproductive endocrinology research.

They act on different hormone systems. Kisspeptin-10 is a decapeptide (YNWNSFGLRF-NH2) that activates the kisspeptin receptor (KISS1R, also called GPR54), studied in research on the reproductive axis and gonadotropin-releasing hormone. Sermorelin is a 29-amino-acid GHRH fragment that acts on the GHRH receptor in the growth hormone axis. They share no sequence.

Despite similar-sounding names, they are unrelated. KPV is a three-amino-acid fragment of α-MSH (Lys-Pro-Val). Kisspeptin-10 is a ten-amino-acid peptide (YNWNSFGLRF-NH2), the C-terminal fragment of kisspeptin, that activates the KISS1 receptor (GPR54) and is studied in reproductive-hormone research. They share no sequence, receptor or research area.

Kisspeptin is the name for a family of peptides cut from the protein encoded by the KISS1 gene, including kisspeptin-54 (also called metastin), -14, -13 and -10. The gene was identified in 1996 in Hershey, Pennsylvania, as a suppressor of cancer metastasis and named after the town's chocolate kisses. In 2003 its receptor, KISS1R (GPR54), was linked to the regulation of puberty, and it has been a major topic in reproductive endocrinology research since.

Research on kisspeptin-10 has examined the kisspeptin receptor (KISS1R) and its control of GnRH and luteinizing-hormone release, in cell, rodent, sheep and primate models. Human physiological studies in reproductive endocrinology have also used kisspeptin peptides, including in healthy volunteers and people with reproductive disorders. It is also studied in cancer biology, given the KISS1 gene's original link to metastasis. Findings in cells or animals do not establish effects in people.

Both are fragments of the same KISS1 precursor and share the same C-terminal ten amino acids, which carry the activity at the kisspeptin receptor. Kisspeptin-54 is the full 54-amino-acid processed peptide (also called metastin). Kisspeptin-10 is only the final ten residues, YNWNSFGLRF-NH2, and is the shortest form with full receptor activity; published studies describe it as cleared more quickly than kisspeptin-54.

Kisspeptin-10 is not FDA approved and is not an approved medicine elsewhere; as of October 2026 it is an investigational and research compound. It is not listed as a federally controlled substance, so it can be bought in the United States as a research chemical for laboratory use, but not sold for human consumption. This is general information, not legal advice.

Both, in a sense. The kisspeptin-10 sequence, YNWNSFGLRF-NH2, occurs naturally as a cleavage product of human kisspeptin. The material sold here is synthetic, made by solid-phase peptide synthesis to that natural sequence and identity-confirmed by mass spectrometry, with purity measured by HPLC on the lot's Certificate of Analysis.

They are very different molecules acting at different points in the reproductive hormone axis. Kisspeptin-10 is a ten-amino-acid peptide that acts on the kisspeptin receptor (KISS1R) in the hypothalamus, upstream of gonadotropin-releasing hormone. HCG is a large glycoprotein hormone of two protein subunits plus sugar chains that acts directly on the LH/CG receptor in the gonads. HCG is an FDA-approved active ingredient; kisspeptin-10 is not.

Yes, for storage. Keep the sealed lyophilized kisspeptin-10 vial refrigerated at 2–8 °C, or frozen at −20 °C for long-term storage. Its sequence contains tryptophan and asparagine residues, which are prone to oxidation and deamidation in solution, so keep reconstituted material refrigerated and avoid repeated freeze-thaw cycles.

KISSPEPTIN-10 (fragment): molecular formula C63H83N17O14; molecular weight 1302.44 g/mol; CAS number 374675-21-5. Sequence: Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe-NH2 (YNWNSFGLRF-NH2). Match these identifiers against the Certificate of Analysis for the lot.

Yes. Each lot has its own Certificate of Analysis, linked on this page for the current lot of each size: 5mg (99.38% HPLC purity); 10mg (99.53% HPLC purity). Past certificates are archived in the COA library; contact us with the lot number on the vial label if a certificate is missing.

99.38% (HPLC, current lot). Purity is measured by high-performance liquid chromatography (HPLC) and reported on the lot's Certificate of Analysis.

KISSPEPTIN-10 (fragment) is supplied as lyophilized powder in a sealed vial in 2 sizes: 5mg, 10mg. In stock and dispatched in 1–2 business days. Quantity pricing applies automatically at 5+ and 10+ vials of the same size.

Store sealed at −20 °C, dry and protected from light.