HGH 191 AA 97%

HGH 191AA is recombinant human growth hormone: a single-chain protein of 191 amino acids (about 22 kDa) held in shape by two disulfide bridges. "191AA" refers to the 191-amino-acid sequence, which is identical to the main form of growth hormone produced by the human pituitary. It is made by recombinant expression rather than chemical synthesis, and ours is supplied as a 97% grade lyophilized powder.

In sequence, yes. Somatropin is the international nonproprietary name for recombinant human growth hormone with the native 191-amino-acid sequence, which is what "191AA" denotes. An earlier recombinant form, somatrem, had 192 residues because of an extra N-terminal methionine. The material sold here is a research-grade reagent, not a pharmaceutical product.

Synthetic peptides are built one amino acid at a time by solid-phase chemical synthesis, which works well up to about 50 residues. Longer chains that must fold into a specific 3D structure, such as 191-amino-acid growth hormone, are made recombinantly: the gene is expressed in cells (commonly E. coli or yeast) and the protein is purified from them. Recombinant proteins are typically checked by methods such as SDS-PAGE and size-exclusion chromatography in addition to HPLC.

Keep the sealed lyophilized vial refrigerated at 2–8 °C and away from light, or frozen at −20 °C for long-term storage. After reconstitution, keep the solution refrigerated, do not freeze it, and avoid shaking, since agitation and freeze-thaw cycles can make proteins aggregate. Follow any storage instructions on the vial label and the lot's Certificate of Analysis.

Human growth hormone (HGH, 191 amino acids) is a pituitary hormone that acts on the growth hormone receptor. IGF-1 is a separate 70-amino-acid hormone, produced largely by the liver in response to growth hormone, that acts on the IGF-1 receptor. IGF-1 LR3 is a recombinant IGF-1 analogue (83 amino acids) with an arginine at position 3 and a 13-residue N-terminal extension that reduce its binding to IGF-binding proteins. It is widely used as a supplement in cell-culture media.

No. AOD 9604 is a 16-amino-acid fragment-based peptide, while human growth hormone (HGH 191AA) is a 191-amino-acid protein of about 22 kDa. AOD 9604 reproduces only the last 15 residues of growth hormone plus an added tyrosine, so it lacks most of the hormone's structure. It is a separate research compound, not a form of HGH.

Yes in sequence. HGH 191AA has the same 191 amino acids as the main 22 kDa form of human growth hormone made by the pituitary. The pituitary also releases smaller amounts of other isoforms, such as a 20 kDa variant missing residues 32–46, so "191AA" specifies the full-length main form. The label also distinguishes it from short synthetic fragments such as HGH 176-191. Ours is recombinant material supplied as a research reagent.

Recombinant human growth hormone is one of the most studied proteins in endocrinology. Laboratory research uses it to examine binding to the growth hormone receptor, JAK2–STAT5 signaling, and the hormone's regulation of IGF-1 production, in cell culture and rodent models, and it serves as a reference standard in assays. Somatropin has also been through extensive human clinical trials and is an FDA-approved active ingredient. Findings in cells or animals do not establish effects in people.

Recombinant human growth hormone (somatropin) is an FDA-approved active ingredient; recombinant growth hormone was first approved in 1985. That approval covers finished medicines made under pharmaceutical manufacturing controls and dispensed by prescription. The HGH 191AA sold here is a research reagent, not a medicine, and is for laboratory research use only.

Technically it is a polypeptide, but at 191 amino acids it is usually called a protein. Chains of up to roughly 50 amino acids are conventionally called peptides; longer chains that fold into a stable three-dimensional structure, as growth hormone does with its four-helix bundle and two disulfide bridges, are called proteins. That is also why HGH 191AA is made by recombinant expression rather than by chemical peptide synthesis.

Sealed, lyophilized HGH is stable for a long time when kept refrigerated at 2–8 °C, and longer frozen at −20 °C; use the expiry or retest date on the label and Certificate of Analysis. Once reconstituted, a protein solution is far less stable: keep it refrigerated, do not freeze it, and use it within the window stated for that lot, typically a few weeks at most. Cloudiness or particles indicate aggregation.

Growth hormone is a folded protein, so gentle handling matters more than with short peptides. Let the sealed vial reach room temperature, add sterile diluent slowly down the inside wall rather than onto the cake, and swirl or roll gently until dissolved; never shake, since agitation can make the protein aggregate. The concentration is the labeled mass divided by the volume added. Label and refrigerate the vial. This is the general reconstitution procedure for recombinant HGH.

They are very different molecules. HGH 191AA is the full-length 191-amino-acid hormone, made by recombinant expression and folded with two disulfide bridges. HGH fragment 176-191 is a short synthetic peptide matching only the last 16 residues of the hormone's C-terminus; AOD 9604 is a closely related synthetic peptide of the same length. A 16-residue fragment does not have the folded structure of the full hormone.

They are unrelated hormones that are often confused because of their initials. HGH (human growth hormone) is a single-chain, 191-amino-acid pituitary protein that acts on the growth hormone receptor. HCG (human chorionic gonadotropin) is a glycoprotein made of two subunits, a 92-residue α chain and a 145-residue β chain, produced mainly by the placenta; it acts on the LH/hCG receptor. Both are sold here as research reagents.

No. HGH is the 191-amino-acid growth hormone itself. Ipamorelin, GHRP-6, hexarelin, sermorelin, CJC-1295 and tesamorelin are much smaller synthetic peptides, called growth hormone secretagogues, that act on pituitary receptors controlling the body's own release of growth hormone: the ghrelin receptor (GHS-R1a) or the GHRH receptor. None of them contains the growth hormone sequence.

No. Thymosin alpha-1 is a 28-amino-acid acetylated peptide cleaved from prothymosin alpha and studied mainly in immunology research. Growth hormone is a 191-amino-acid pituitary protein with its own receptor. The two share no sequence and act on different targets; the "thymosin" name refers to the thymus tissue where it was first isolated.

No. Tesamorelin is a 44-amino-acid synthetic peptide, an analogue of growth-hormone-releasing hormone (GHRH), the hypothalamic hormone that signals the pituitary through the GHRH receptor. Growth hormone (HGH) is a different and much larger molecule, a 191-amino-acid protein made by the pituitary. Tesamorelin contains none of the growth hormone sequence.

No. Sermorelin is a 29-amino-acid peptide, the active N-terminal fragment of growth-hormone-releasing hormone (GHRH). HGH is growth hormone itself, a 191-amino-acid protein made by the pituitary. Sermorelin acts on the GHRH receptor, upstream of growth hormone, and contains none of the growth hormone sequence.

No. Ipamorelin is a 5-amino-acid synthetic peptide (Aib-His-D-2-Nal-D-Phe-Lys-NH2), classed as a growth hormone secretagogue because it acts on the ghrelin receptor, one of the pituitary receptors that regulate growth hormone release. Growth hormone (HGH) itself is a 191-amino-acid protein. Ipamorelin contains none of its sequence.

No. GHRP-6 is a 6-amino-acid synthetic peptide that acts on the ghrelin receptor, one of the pituitary receptors that regulate growth hormone release. HGH is the 191-amino-acid growth hormone protein itself. Despite the similar names, GHRP-6 contains no part of the growth hormone sequence.

MGF is not a form of IGF-1 hormone itself. It is a 24-amino-acid peptide matching the E-domain, the C-terminal tail of the IGF-1Ec precursor that is cut off when mature IGF-1 is made. IGF-1 is the 70-amino-acid hormone that binds the IGF-1 receptor, and HGH is a 191-amino-acid pituitary protein. The three share no active sequence.

HGH 191 AA 97%: molecular formula C990H1528N262O300S7; molecular weight approximately 22,124 Da; CAS number 12629-01-5. Sequence: 191-amino-acid single-chain polypeptide identical to the mature human GH1 gene product, with disulfide bridges Cys53-Cys165 and Cys182-Cys189. Match these identifiers against the Certificate of Analysis for the lot.

Yes. Each lot has its own Certificate of Analysis, linked on this page for the current lot of each size: 10iu (99.86% HPLC purity); 24iu (98.9% HPLC purity). Past certificates are archived in the COA library; contact us with the lot number on the vial label if a certificate is missing.

97% grade (HPLC). Purity is measured by high-performance liquid chromatography (HPLC) and reported on the lot's Certificate of Analysis.

HGH 191 AA 97% is supplied as lyophilized powder in a sealed vial in 2 sizes: 10iu, 24iu. In stock and dispatched in 1–2 business days. Quantity pricing applies automatically at 5+ and 10+ vials of the same size.

Store sealed at −20 °C, dry and protected from light.