Melanotan 1 (MT-1)

Both are synthetic analogues of α-melanocyte-stimulating hormone that act on melanocortin receptors. Melanotan 1 (afamelanotide) is a linear 13-amino-acid peptide with Nle4 and D-Phe7 substitutions, and it is an approved active ingredient in a prescription implant. Melanotan 2 is a smaller cyclic heptapeptide that binds several melanocortin receptor subtypes; it has never been approved anywhere.

Melanotan 1 (MT-1, also known as afamelanotide) is a linear 13-amino-acid analogue of α-melanocyte-stimulating hormone, Ac-Ser-Tyr-Ser-Nle-Glu-His-D-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2. It is the natural α-MSH sequence with two substitutions, norleucine at position 4 and D-phenylalanine at position 7, that make it more resistant to breakdown. It was developed at the University of Arizona and acts mainly on the MC1 receptor.

Yes, as an active ingredient. Afamelanotide, the generic name for Melanotan 1, was approved by the FDA in 2019 as the active ingredient of a prescription implant, and it is also approved in the European Union. The material sold here is a research reagent, not that medicine, and is not approved for any human or veterinary use.

Research on Melanotan 1 has examined MC1 receptor signaling and melanin synthesis in pigment cells and animal models. As afamelanotide, it has been investigated in clinical trials in people with erythropoietic protoporphyria, a rare light-sensitivity disorder, and in other pigmentation-related conditions such as vitiligo. Findings in cells or animals do not establish effects in people.

Melanotan 1 (MT-1): molecular formula C78H111N21O19; molecular weight 1646.85 g/mol; CAS number 75921-69-6. Sequence: Ac-Ser-Tyr-Ser-Nle-Glu-His-D-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2. Match these identifiers against the Certificate of Analysis for the lot.

Yes. Each lot has its own Certificate of Analysis, linked on this page for the current lot of each size: 10mg (99.68% HPLC purity). Past certificates are archived in the COA library; contact us with the lot number on the vial label if a certificate is missing.

99.68% (HPLC, current lot). Purity is measured by high-performance liquid chromatography (HPLC) and reported on the lot's Certificate of Analysis.

Melanotan 1 (MT-1) is supplied as lyophilized powder in a sealed vial: 10mg. In stock and dispatched in 1–2 business days. Quantity pricing applies automatically at 5+ and 10+ vials of the same size.

Store sealed at −20 °C, dry and protected from light.